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CREB
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Belongs to the bZIP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
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Cellular Component:
ATF4-CREB1 transcription factor complex; axon; chromatin; euchromatin; mitochondrial matrix; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex
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Molecular Function:
arrestin family protein binding; cAMP response element binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; Hsp70 protein binding; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coactivator binding
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Biological Process:
axonogenesis; cAMP-mediated signaling; cellular response to fatty acid; cellular response to forskolin; cellular response to growth factor stimulus; cellular response to hepatocyte growth factor stimulus; cellular response to insulin-like growth factor stimulus; cellular response to leukemia inhibitory factor; cellular response to nerve growth factor stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; cellular response to zinc ion; chemotaxis to arachidonic acid; circadian rhythm; hormone secretion; lactation; lung epithelium development; lung saccule development; mammary gland development; memory; mRNA transcription by RNA polymerase II; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of transcription by competitive promoter binding; osteoclast differentiation; pituitary gland development; positive regulation of apoptotic process; positive regulation of cardiac muscle tissue development; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of long-term synaptic potentiation; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta3 production; protein stabilization; regulation of apoptotic process; regulation of cell size; regulation of DNA-templated transcription; regulation of fibroblast proliferation; regulation of glial cell proliferation; regulation of testosterone biosynthetic process; regulation of transcription by RNA polymerase II; response to activity; response to dehydroepiandrosterone; response to erythropoietin; response to glucagon; response to hypobaric hypoxia; response to hypoxia; response to inorganic substance; response to L-glutamate; response to nicotine; response to organic substance; response to purine-containing compound; response to xenobiotic stimulus; secretory granule organization; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; type I pneumocyte differentiation; visual learning
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Reference #:
P15337
(UniProtKB)
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Alt. Names/Synonyms: cAMP response element binding protein 1; cAMP-responsive element-binding protein 1; Creb-1; Creb1; Cyclic AMP-responsive element-binding protein 1; Y protein
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Gene Symbols: Creb1
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Molecular weight:
35,081 Da
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Basal Isoelectric point:
5.19
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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Inhibition of Apoptosis
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Parkinson's Disease
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Regulation of P38 MAPKs
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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