LNX1
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. Expressed in heart, placenta, kidney, pancreas and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
Chromosomal Location of human Ortholog: 4q12 |
Cellular Component:
cytoplasm
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Molecular Function:
identical protein binding; metal ion binding; PDZ domain binding; protein binding; ubiquitin-protein transferase activity
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Biological Process:
protein ubiquitination; ubiquitin-dependent protein catabolic process
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Reference #:
Q8TBB1
(UniProtKB)
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Alt. Names/Synonyms: E3 ubiquitin-protein ligase LNX; Ligand of Numb-protein X 1; ligand of numb-protein X 1, E3 ubiquitin protein ligase; LNX; LNX1; MPDZ; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX; Numb-binding protein 1; PDZ domain-containing ring finger protein 2; PDZRN2; RING-type E3 ubiquitin transferase LNX
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Gene Symbols: LNX1
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Molecular weight:
80,629 Da
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Basal Isoelectric point:
6.67
Predict pI for various phosphorylation states
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