LNX1 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. Expressed in heart, placenta, kidney, pancreas and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 4q12
Cellular Component:  cytoplasm
Molecular Function:  metal ion binding; PDZ domain binding; protein binding; ubiquitin-protein transferase activity
Biological Process:  protein homooligomerization; protein ubiquitination; ubiquitin-dependent protein catabolic process
Reference #:  Q8TBB1 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase LNX; Ligand of Numb-protein X 1; ligand of numb-protein X 1, E3 ubiquitin protein ligase; LNX; LNX1; MPDZ; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX; Numb-binding protein 1; PDZ domain-containing ring finger protein 2; PDZRN2; RING-type E3 ubiquitin transferase LNX
Gene Symbols: LNX1
Molecular weight: 80,629 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein