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DBP
This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. Belongs to the bZIP family. PAR subfamily. Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 19q13.33 |
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Cellular Component:
chromatin; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; rhythmic process
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Reference #:
Q10586
(UniProtKB)
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Alt. Names/Synonyms: Albumin D box-binding protein; Albumin D-element-binding protein; D site of albumin promoter (albumin D-box) binding protein; D site-binding protein; D-box binding PAR bZIP transcription factor; DABP; DBP; Tax-responsive enhancer element-binding protein 302; TaxREB302
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Gene Symbols: DBP
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Molecular weight:
34,349 Da
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Basal Isoelectric point:
9.34
Predict pI for various phosphorylation states
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