CRMP-4 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 5q32
Cellular Component:  cell body; cytosol; extracellular space; filamentous actin; growth cone; lamellipodium; synapse
Molecular Function:  chondroitin sulfate binding; filamin binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; protein binding; SH3 domain binding
Biological Process:  actin crosslink formation; actin filament bundle assembly; cellular response to cytokine stimulus; negative regulation of cell migration; negative regulation of neuron projection development; neuron development; positive regulation of filopodium assembly; positive regulation of neuron projection development; protein homooligomerization; response to axon injury
Reference #:  Q14195 (UniProtKB)
Alt. Names/Synonyms: CRMP4; dihydropyrimidinase-like 3; Dihydropyrimidinase-related protein 3; DPYSL3; DRP3; ULIP; ULIP1
Gene Symbols: DPYSL3
Molecular weight: 61,963 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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