OTOP1 Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly-sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates purinergic control of intracellular calcium in vestibular supporting cells. May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol. Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction. Belongs to the otopetrin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 4p16.3
Cellular Component:  membrane; plasma membrane
Molecular Function:  proton channel activity
Biological Process:  biomineral tissue development; cellular response to insulin stimulus; detection of gravity; inner ear morphogenesis; negative regulation of type II interferon-mediated signaling pathway; proton transmembrane transport
Reference #:  Q7RTM1 (UniProtKB)
Alt. Names/Synonyms: hOtop1; MGC163302; MGC163304; OTOP1; otopetrin 1; Otopetrin-1; Proton channel OTOP1; Q7RTM1
Gene Symbols: OTOP1
Molecular weight: 67,353 Da
Basal Isoelectric point: 8.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein