FAAH Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Belongs to the amidase family. Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p33
Cellular Component:  cytoskeleton; endoplasmic reticulum membrane; integral component of membrane; organelle membrane
Molecular Function:  acylglycerol lipase activity; amidase activity; anandamide amidohydrolase activity; fatty acid amide hydrolase activity; oleamide hydrolase activity; protein binding
Biological Process:  arachidonic acid metabolic process; fatty acid catabolic process; monoacylglycerol catabolic process
Disease: Polysubstance Abuse, Susceptibility To
Reference #:  O00519 (UniProtKB)
Alt. Names/Synonyms: Anandamide amidohydrolase 1; FAAH; FAAH-1; FAAH1; fatty acid amide hydrolase; Fatty acid ester hydrolase; Fatty-acid amide hydrolase 1; MGC102823; MGC138146; Oleamide hydrolase 1; PSAB
Gene Symbols: FAAH
Molecular weight: 63,066 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene