RTCB Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Belongs to the RtcB family. Note: This description may include information from UniProtKB.
Protein type: EC
Chromosomal Location of human Ortholog: 22q12.3
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; nuclear envelope; nucleoplasm; nucleus; tRNA-splicing ligase complex
Molecular Function:  GTP binding; metal ion binding; protein binding; RNA ligase (ATP) activity; vinculin binding
Biological Process:  in utero embryonic development; placenta development; tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate; tRNA splicing, via endonucleolytic cleavage and ligation
Reference #:  Q9Y3I0 (UniProtKB)
Alt. Names/Synonyms: 3'-phosphate/5'-hydroxy nucleic acid ligase; ankyrin repeat domain 54; C22orf28; DJ149A16.6; FAAP; focal adhesion-associated protein; HSPC117; RNA 2',3'-cyclic phosphate and 5'-OH ligase; RNA-splicing ligase RtcB homolog; RP1-149A16.6; RTCB; tRNA-splicing ligase RtcB homolog
Gene Symbols: RTCB
Molecular weight: 55,210 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB