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RTCB
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Belongs to the RtcB family. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.5.1.3 |
| Chromosomal Location of human Ortholog: 22q12.3 |
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Cellular Component:
cytoplasm; cytosol; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; nuclear envelope; nucleoplasm; nucleus; tRNA-splicing ligase complex
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Molecular Function:
GTP binding; metal ion binding; protein binding; RNA ligase (ATP) activity; vinculin binding
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Biological Process:
in utero embryonic development; placenta development; tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate; tRNA splicing, via endonucleolytic cleavage and ligation
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Reference #:
Q9Y3I0
(UniProtKB)
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Alt. Names/Synonyms: 3'-phosphate/5'-hydroxy nucleic acid ligase; ankyrin repeat domain 54; C22orf28; DJ149A16.6; FAAP; focal adhesion-associated protein; HSPC117; RNA 2',3'-cyclic phosphate and 5'-OH ligase; RNA-splicing ligase RtcB homolog; RP1-149A16.6; RTCB; tRNA-splicing ligase RtcB homolog
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Gene Symbols: RTCB
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Molecular weight:
55,210 Da
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Basal Isoelectric point:
6.77
Predict pI for various phosphorylation states
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