CDC34 a member of the ubiquitin-conjugating enzyme family. Is a part of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for ubiquitin-mediated degradation of cell cycle G1 regulators. Required for the initiation of DNA replication. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function:  ATP binding; protein binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity
Biological Process:  cellular protein modification process; cellular response to interferon-beta; DNA replication initiation; G1/S transition of mitotic cell cycle; negative regulation of cAMP-mediated signaling; positive regulation of inclusion body assembly; positive regulation of neuron apoptotic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination; response to growth factor
Reference #:  P49427 (UniProtKB)
Alt. Names/Synonyms: CDC34; cell division cycle 34 homolog (S. cerevisiae); E2-CDC34; UB2R1; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; Ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1
Gene Symbols: CDC34
Molecular weight: 26,737 Da
Basal Isoelectric point: 4.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDC34

Protein Structure Not Found.


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