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KIF2A iso4
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motor |
| Chromosomal Location of human Ortholog: 5q12.1 |
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Cellular Component:
centriolar subdistal appendage; centriole; centrosome; cytoplasm; cytosol; kinesin complex; microtubule; nuclear body; nucleolus; nucleoplasm; spindle; spindle microtubule; spindle pole
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Molecular Function:
ATP binding; ATP hydrolysis activity; cytoskeletal motor activity; microtubule binding; microtubule motor activity; protein binding
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Biological Process:
cell differentiation; cell division; microtubule cytoskeleton organization; microtubule depolymerization; microtubule-based movement; mitotic spindle assembly; mitotic spindle organization; nervous system development; regulation of cell migration
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Reference #:
O00139-4
(UniProtKB)
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Alt. Names/Synonyms: CDCBM3; hK2; KIF2; KIF2A; kinesin family member 2A; kinesin heavy chain member 2A; Kinesin, heavy chain, 2; Kinesin-2; Kinesin-like protein KIF2A; KNS2
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Gene Symbols: KIF2A
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Molecular weight:
84,089 Da
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Basal Isoelectric point:
6.01
Predict pI for various phosphorylation states
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