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AP3B2 iso4
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Belongs to the adaptor complexes large subunit family. Isoform 1 expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression) (PubMed:1851215). Isoform 2 is expressed at high levels in brain and testis (PubMed:17453999). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of human Ortholog: 15q25.2 |
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Cellular Component:
AP-3 adaptor complex; axon cytoplasm; clathrin-coated vesicle membrane; early endosome; Golgi apparatus; intracellular vesicle; presynapse
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Biological Process:
anterograde axonal transport; anterograde synaptic vesicle transport; clathrin-coated vesicle cargo loading, AP-3-mediated; intracellular protein transport; intracellular transport; synaptic vesicle coating; synaptic vesicle recycling; vesicle-mediated transport
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Reference #:
Q13367-4
(UniProtKB)
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Alt. Names/Synonyms: Adapter-related protein complex 3 subunit beta-2; Adaptor protein complex AP-3 subunit beta-2; adaptor related protein complex 3 beta 2 subunit; adaptor related protein complex 3 subunit beta 2; Adaptor-related protein complex 3 subunit beta-2; adaptor-related protein complex 3, beta 2 subunit; AP-3 complex subunit beta-2; AP3B2; Beta-3B-adaptin; Clathrin assembly protein complex 3 beta-2 large chain; DKFZp686D17136; EIEE48; NAPTB; Neuron-specific vesicle coat protein beta-NAP; Neuronal adaptin-like protein, beta-subunit
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Gene Symbols: AP3B2
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Molecular weight:
121,189 Da
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Basal Isoelectric point:
5.29
Predict pI for various phosphorylation states
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