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WASP
Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
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Cellular Component:
actin filament; cell-cell junction; cytosol; nucleus; phagocytic vesicle; plasma membrane; site of double-strand break; vesicle membrane
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Molecular Function:
actin binding; identical protein binding; phospholipase binding; protein kinase binding; SH3 domain binding; small GTPase binding
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Biological Process:
actin filament polymerization; actin filament-based movement; actin polymerization or depolymerization; Cdc42 protein signal transduction; cellular response to type II interferon; endosomal transport; immune response; negative regulation of cell motility; negative regulation of stress fiber assembly; positive regulation of double-strand break repair via homologous recombination; positive regulation of transcription by RNA polymerase II; regulation of actin polymerization or depolymerization; regulation of double-strand break repair via nonhomologous end joining; regulation of lamellipodium assembly; regulation of stress fiber assembly; regulation of T cell antigen processing and presentation; Rho protein signal transduction; T cell activation
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Reference #:
G3V9K5
(UniProtKB)
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Alt. Names/Synonyms: WASP; WASP actin nucleation promoting factor; Wiskott-Aldrich syndrome homolog; wiskott-Aldrich syndrome protein
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Gene Symbols: Was
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Molecular weight:
38,574 Da
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Basal Isoelectric point:
6.33
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Adherens Junction Dynamics
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T Cell Receptor Signaling
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