DPM1 Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Belongs to the glycosyltransferase 2 family. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - N-glycan biosynthesis; Transferase
Cellular Component:  dolichol-phosphate-mannose synthase complex; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane
Molecular Function:  alcohol binding; dolichyl-phosphate beta-D-mannosyltransferase activity; dolichyl-phosphate-mannose-protein mannosyltransferase activity; mannose binding
Biological Process:  dolichol metabolic process; GDP-mannose metabolic process; GPI anchor biosynthetic process; mannosylation; protein mannosylation; protein O-linked mannosylation
Reference #:  D4A8N1 (UniProtKB)
Alt. Names/Synonyms: dolichol-phosphate (beta-D) mannosyltransferase 1; dolichol-phosphate mannosyltransferase subunit 1; dolichyl-phosphate mannosyltransferase 1; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit; dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Gene Symbols: Dpm1
Molecular weight: 29,250 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene