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DPM1
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Belongs to the glycosyltransferase 2 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.1.83; Glycan Metabolism - N-glycan biosynthesis; Transferase |
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Cellular Component:
dolichol-phosphate-mannose synthase complex; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane
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Molecular Function:
alcohol binding; dolichyl-phosphate beta-D-mannosyltransferase activity; dolichyl-phosphate-mannose-protein mannosyltransferase activity; mannose binding
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Biological Process:
dolichol metabolic process; GDP-mannose metabolic process; GPI anchor biosynthetic process; mannosylation; protein mannosylation; protein O-linked mannosylation
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Reference #:
D4A8N1
(UniProtKB)
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Alt. Names/Synonyms: dolichol-phosphate (beta-D) mannosyltransferase 1; dolichol-phosphate mannosyltransferase subunit 1; dolichyl-phosphate mannosyltransferase 1; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit; dolichyl-phosphate mannosyltransferase subunit 1, catalytic
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Gene Symbols: Dpm1
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Molecular weight:
29,250 Da
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Basal Isoelectric point:
9.5
Predict pI for various phosphorylation states
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