RGS16 Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. Abundantly expressed in retina with lower levels of expression in most other tissues. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of mouse Ortholog: 1 G3|1 65.43 cM
Cellular Component:  cytoplasm; membrane
Molecular Function:  GTPase activator activity; protein binding
Biological Process:  G protein-coupled receptor signaling pathway; negative regulation of signal transduction; positive regulation of GTPase activity
Reference #:  P97428 (UniProtKB)
Alt. Names/Synonyms: A28-RGS14P; OTTMUSP00000022875; Regulator of G-protein signaling 16; Retinal-specific RGS; Retinally abundant regulator of G-protein signaling; RGS-r; Rgs14; RGS16; Rgsr
Gene Symbols: Rgs16
Molecular weight: 22,691 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein