RGS16 belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of Human Ortholog: 1 G3|1 65.43 cM
Cellular Component:  cytoplasm; intrinsic component of membrane; membrane; membrane raft
Molecular Function:  GTPase activator activity; protein binding
Biological Process:  G protein-coupled receptor signaling pathway; negative regulation of signal transduction; positive regulation of GTPase activity
Reference #:  P97428 (UniProtKB)
Alt. Names/Synonyms: A28-RGS14P; OTTMUSP00000022875; Regulator of G-protein signaling 16; Retinal-specific RGS; Retinally abundant regulator of G-protein signaling; RGS-r; Rgs14; RGS16; Rgsr
Gene Symbols: Rgs16
Molecular weight: 22,691 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene