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S100A14
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. Belongs to the S-100 family. Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
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Cellular Component:
perinuclear region of cytoplasm
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Molecular Function:
chemokine receptor binding
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Biological Process:
defense response to bacterium; positive regulation of granulocyte chemotaxis; positive regulation of monocyte chemotaxis; response to lipopolysaccharide; toll-like receptor 4 signaling pathway
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Reference #:
NP_001258241
(RefSeq)
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Alt. Names/Synonyms: protein S100-A14; S100 calcium binding protein A14; S100a14
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Gene Symbols: S100a14
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Molecular weight:
11,579 Da
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Basal Isoelectric point:
5.02
Predict pI for various phosphorylation states
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