SEPT6 Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Hydrolase
Chromosomal Location of Human Ortholog: X|X A3.3
Cellular Component:  axon terminus; cell projection; chromosome; chromosome, centromeric region; cilium; cleavage furrow; cytoplasm; cytoskeleton; kinetochore; microtubule cytoskeleton; motile cilium; presynapse; septin collar; septin complex; septin ring; sperm annulus; synaptic vesicle
Molecular Function:  GTP binding; GTPase activity; nucleotide binding; protein binding
Biological Process:  cell cycle; cell differentiation; cell division; cilium assembly; cytoskeleton-dependent cytokinesis; spermatogenesis
Reference #:  Q9R1T4 (UniProtKB)
Alt. Names/Synonyms: 2810035H17Rik; C920001C06Rik; Kiaa0128; mKIAA0128; OTTMUSP00000018594; Sep; Sep6; Sept6; septin 6; Septin-6; Septin6
Gene Symbols: Sept6
Molecular weight: 49,620 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene