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E2F5
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Belongs to the E2F/DP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
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Cellular Component:
cytoplasm; fibrillar center; intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; sarcoplasm; transcription regulator complex
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Molecular Function:
DNA-binding transcription activator activity; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding
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Biological Process:
animal organ morphogenesis; cell projection organization; positive regulation of DNA-templated transcription; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
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Reference #:
F1LRB5
(UniProtKB)
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Alt. Names/Synonyms: E2F-5; E2F5; Transcription factor E2F5
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Gene Symbols: E2f5
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Molecular weight:
36,889 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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G1/S Checkpoint
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