RNF138 E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Cellular Component: 
Reference #:  Q99PD2 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF138; RING finger protein 138; RING-type E3 ubiquitin transferase RNF138; RN138
Gene Symbols: Rnf138
Molecular weight: 24,072 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
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RNF138

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept