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HIF2A
Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
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Cellular Component:
cytoplasm; nuclear speck; nucleus; transcription regulator complex
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Molecular Function:
cis-regulatory region sequence-specific DNA binding; cobalt ion binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein dimerization activity; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator binding
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Biological Process:
angiogenesis; blood vessel remodeling; cell differentiation; cellular response to hypoxia; cellular response to interleukin-1; cellular response to lipopolysaccharide; embryonic placenta development; epithelial cell maturation; erythrocyte differentiation; gene expression; hemopoiesis; lung development; mitochondrion organization; mRNA transcription by RNA polymerase II; multicellular organismal-level iron ion homeostasis; myoblast fate commitment; negative regulation of transcription by RNA polymerase II; norepinephrine biosynthetic process; norepinephrine metabolic process; positive regulation of cold-induced thermogenesis; positive regulation of dopamine biosynthetic process; positive regulation of lung alveolus development; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of heart rate; regulation of protein neddylation; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; response to hypoxia; response to oxidative stress; surfactant homeostasis; transcription by RNA polymerase II; visual perception
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Reference #:
Q9JHS1
(UniProtKB)
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Alt. Names/Synonyms: Endothelial PAS domain-containing protein 1; EPAS-1; EPAS1; HIF-2-alpha; HIF2-alpha; Hif2a; Hypoxia-inducible factor 2-alpha
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Gene Symbols: Epas1
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Molecular weight:
96,718 Da
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Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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