AI428936
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus. Belongs to the nesprin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral |
Cellular Component:
meiotic nuclear membrane microtubule tethering complex; nuclear outer membrane
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Biological Process:
establishment of epithelial cell apical/basal polarity
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Reference #:
Q5M844
(UniProtKB)
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Alt. Names/Synonyms: KASH domain-containing protein 4; KASH4; Nesprin-4; Nuclear envelope spectrin repeat protein 4; SYNE4
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Gene Symbols: Syne4
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Molecular weight:
36,515 Da
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Basal Isoelectric point:
5.48
Predict pI for various phosphorylation states
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