JMJD2D Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase
Cellular Component:  chromatin; nucleus; pericentric heterochromatin; site of double-strand break
Molecular Function:  chromatin DNA binding; damaged DNA binding; histone demethylase activity; histone H3K9 demethylase activity; histone H3K9me2/H3K9me3 demethylase activity; metal ion binding
Biological Process:  cellular response to ionizing radiation; chromatin remodeling; DNA damage response; double-strand break repair via homologous recombination; positive regulation of chromatin binding; positive regulation of double-strand break repair via nonhomologous end joining; regulation of gene expression; regulation of protein phosphorylation
Reference #:  A1A5Q5 (UniProtKB)
Alt. Names/Synonyms: "Jhdm3d; [histone H3]-trimethyl-L-lysine(9) demethylase 4D; JmjC domain-containing histone demethylation protein 3D; Jmjd2d"; Jumonji domain-containing protein 2D; KDM4D; Lysine-specific demethylase 4D
Gene Symbols: Kdm4d
Molecular weight: 57,188 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
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JMJD2D

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein