ADAM15
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells. 13 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease |
Cellular Component:
acrosomal vesicle; adherens junction; cell surface; extracellular exosome; extracellular space; membrane; motile cilium
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Molecular Function:
integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; SH3 domain binding
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Biological Process:
angiogenesis; apoptotic process; cardiac epithelial to mesenchymal transition; cell-cell adhesion; cellular response to phorbol 13-acetate 12-myristate; collagen catabolic process; immune response to tumor cell; innate immune response; integrin-mediated signaling pathway; male gonad development; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell-matrix adhesion; negative regulation of receptor binding; proteolysis; response to hypobaric hypoxia; tissue regeneration
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Reference #:
Q9QYV0
(UniProtKB)
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Alt. Names/Synonyms: "ADAM 15; ADA15; CRII-7; Disintegrin and metalloproteinase domain-containing protein 15; MDC-15; Mdc15; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metargidin"
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Gene Symbols: Adam15
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Molecular weight:
93,308 Da
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Basal Isoelectric point:
5.68
Predict pI for various phosphorylation states
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