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MFGE8
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin is the main constituent of aortic medial amyloid. Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
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Cellular Component:
acrosomal membrane; external side of plasma membrane; extracellular space
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Molecular Function:
integrin binding; phosphatidylethanolamine binding; phosphatidylserine binding
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Biological Process:
angiogenesis; apoptotic cell clearance; cell adhesion; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of cell population proliferation; positive regulation of phagocytosis; response to estrogen; single fertilization
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Reference #:
P70490
(UniProtKB)
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Alt. Names/Synonyms: Ags; Lactadherin; MFG-E8; MFGM; Milk fat globule-EGF factor 8; O-acetyl GD3 ganglioside synthase; SED1
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Gene Symbols: Mfge8
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Molecular weight:
47,413 Da
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Basal Isoelectric point:
6.74
Predict pI for various phosphorylation states
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