IL-1RA Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. Belongs to the interleukin-1 receptor family. Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine
Cellular Component:  axon; cell surface; external side of plasma membrane; extracellular space; membrane; plasma membrane; protein-containing complex
Molecular Function:  hydrolase activity; interleukin-1 binding; interleukin-1 receptor activity; interleukin-1, type I, activating receptor activity; ionotropic glutamate receptor binding; NAD(P)+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; platelet-derived growth factor receptor binding; protease binding; protein binding
Biological Process:  cellular response to glucose stimulus; cytokine-mediated signaling pathway; heat acclimation; inflammatory response; interleukin-1-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; positive regulation of neuron migration; positive regulation of neutrophil extravasation; positive regulation of T-helper 1 cell cytokine production; positive regulation of type II interferon production; regulation of inflammatory response; response to epidermal growth factor; response to interleukin-1; response to nitric oxide; response to odorant; response to transforming growth factor beta
Reference #:  Q02955 (UniProtKB)
Alt. Names/Synonyms: "Interleukin-1 receptor type 1, soluble form"; CD121 antigen-like family member A; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; IL1R1; Il1ra; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type I; mIL-1R1; mIL-1RI; p80; sIL-1R1; sIL-1RI
Gene Symbols: Il1r1
Molecular weight: 66,759 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Select Structure to View Below

IL-1RA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein