NEK8 Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor)
Cellular Component: 
Reference #:  D3ZGQ5 (UniProtKB)
Alt. Names/Synonyms: Jck; NEK8; Never in mitosis A-related kinase 8; NimA-related protein kinase 8; Serine/threonine-protein kinase Nek8
Gene Symbols: Nek8
Molecular weight: 75,254 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein