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SERT
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. Expressed in platelets (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter |
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Cellular Component:
endomembrane system; endosome membrane; focal adhesion; membrane raft; neuron projection; plasma membrane; postsynaptic membrane; presynapse; presynaptic membrane; serotonergic synapse; synapse
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Molecular Function:
actin filament binding; antiporter activity; cocaine binding; identical protein binding; integrin binding; monoamine transmembrane transporter activity; monoatomic cation channel activity; neurotransmitter transmembrane transporter activity; nitric-oxide synthase binding; protein binding; serotonin binding; serotonin:sodium:chloride symporter activity; sodium ion binding; syntaxin-1 binding
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Biological Process:
brain morphogenesis; cellular response to cGMP; cellular response to organic substance; cellular response to retinoic acid; circadian rhythm; enteric nervous system development; locomotory behavior; membrane depolarization; memory; monoamine transport; negative regulation of cerebellar granule cell precursor proliferation; negative regulation of neuron differentiation; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; neurotransmitter reuptake; neurotransmitter transport; platelet aggregation; positive regulation of cell cycle; positive regulation of gene expression; positive regulation of serotonin secretion; regulation of thalamus size; response to estradiol; response to hypoxia; response to nutrient; response to organic substance; response to toxic substance; response to xenobiotic stimulus; serotonin transport; serotonin uptake; social behavior; sodium ion transmembrane transport; sperm ejaculation; vasoconstriction
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Reference #:
P31652
(UniProtKB)
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Alt. Names/Synonyms: 5HT transporter; 5HTT; SC6A4; SERT; Sodium-dependent serotonin transporter; Solute carrier family 6 member 4
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Gene Symbols: Slc6a4
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Molecular weight:
70,172 Da
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Basal Isoelectric point:
5.75
Predict pI for various phosphorylation states
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