DNPH1 Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family. Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.2.2.-; Hydrolase
Chromosomal Location of Human Ortholog: 17|17 C
Cellular Component:  cytoplasm; nucleus
Molecular Function:  deoxyribonucleoside 5'-monophosphate N-glycosidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; identical protein binding; protein homodimerization activity
Biological Process:  deoxyribonucleoside monophosphate catabolic process; metabolic process; nucleotide metabolic process; positive regulation of cell growth
Reference #:  Q80VJ3 (UniProtKB)
Alt. Names/Synonyms: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; BC048355; c-Myc-responsive protein Rcl; C76683; cDNA sequence BC048355; Deoxyribonucleoside 5'-monophosphate N-glycosidase; MGC54855; putative c-Myc-responsive; Rcl
Gene Symbols: Rcl
Molecular weight: 18,977 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
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DNPH1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene