DNPH1 Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. Monomer and homodimer. Expression is induced by ETV1. Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. Belongs to the deoxyribonucleoside 5'-monophosphate N- glycosidase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.2.2.-; Hydrolase
Chromosomal Location of Human Ortholog: 17|17 C
Cellular Component:  cytoplasm; nucleus
Molecular Function:  deoxyribonucleoside 5'-monophosphate N-glycosidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; identical protein binding; protein homodimerization activity
Biological Process:  deoxyribonucleoside monophosphate catabolic process; metabolic process; nucleotide metabolic process; positive regulation of cell growth
Reference #:  Q80VJ3 (UniProtKB)
Alt. Names/Synonyms: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; BC048355; c-Myc-responsive protein Rcl; C76683; cDNA sequence BC048355; Deoxyribonucleoside 5'-monophosphate N-glycosidase; MGC54855; putative c-Myc-responsive; Rcl
Gene Symbols: Rcl
Molecular weight: 18,977 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
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DNPH1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene