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H3-2
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 1q21.1 |
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Cellular Component:
nucleosome; nucleus
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Molecular Function:
DNA binding; protein heterodimerization activity; structural constituent of chromatin
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Reference #:
Q5TEC6
(UniProtKB)
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Alt. Names/Synonyms: H3-2; H3.2 histone (putative); H3PS2; HIST2H3PS2; histone 2, H3, pseudogene 2; histone cluster 2 H3 pseudogene 2; Histone HIST2H3PS2; MGC126031; p06
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Gene Symbols: H3-2
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Molecular weight:
15,299 Da
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Basal Isoelectric point:
11.27
Predict pI for various phosphorylation states
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| Select Structure to View Below |
H3-2
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