H3-2 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 1q21.1
Cellular Component:  nucleosome; nucleus
Molecular Function:  DNA binding; protein heterodimerization activity; structural constituent of chromatin
Reference #:  Q5TEC6 (UniProtKB)
Alt. Names/Synonyms: H3-2; H3.2 histone (putative); H3PS2; HIST2H3PS2; histone 2, H3, pseudogene 2; histone cluster 2 H3 pseudogene 2; Histone HIST2H3PS2; MGC126031; p06
Gene Symbols: H3-2
Molecular weight: 15,299 Da
Basal Isoelectric point: 11.27  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein