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MCM4
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Belongs to the MCM family. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication; EC 3.6.4.12 |
| Chromosomal Location of human Ortholog: 8q11.21 |
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Cellular Component:
CMG complex; MCM complex; nucleoplasm; nucleus
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Molecular Function:
ATP binding; ATP hydrolysis activity; DNA helicase activity; protein binding; single-stranded DNA binding; single-stranded DNA helicase activity
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Biological Process:
DNA replication; DNA strand elongation involved in DNA replication; DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; mitotic DNA replication initiation; regulation of DNA-templated DNA replication initiation
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Disease: Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect
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Reference #:
P33991
(UniProtKB)
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Alt. Names/Synonyms: CDC21; CDC21 homolog; CDC54; DNA replication licensing factor MCM4; hCdc21; homolog of S. pombe cell devision cycle 21; IMD54; MCM4; MCM4 minichromosome maintenance deficient 4; MGC33310; minichromosome maintenance complex component 4; minichromosome maintenance deficient 4; NKCD; NKGCD; P1-CDC21
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Gene Symbols: MCM4
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Molecular weight:
96,558 Da
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Basal Isoelectric point:
6.28
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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