MCM4 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Belongs to the MCM family. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC
Chromosomal Location of human Ortholog: 8q11.21
Cellular Component:  CMG complex; MCM complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; ATP hydrolysis activity; DNA helicase activity; protein binding; single-stranded DNA binding; single-stranded DNA helicase activity
Biological Process:  DNA replication; DNA strand elongation involved in DNA replication; DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; mitotic DNA replication initiation; regulation of DNA-templated DNA replication initiation
Disease: Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect
Reference #:  P33991 (UniProtKB)
Alt. Names/Synonyms: CDC21; CDC21 homolog; CDC54; DNA replication licensing factor MCM4; hCdc21; homolog of S. pombe cell devision cycle 21; IMD54; MCM4; MCM4 minichromosome maintenance deficient 4; MGC33310; minichromosome maintenance complex component 4; minichromosome maintenance deficient 4; NKCD; NKGCD; P1-CDC21
Gene Symbols: MCM4
Molecular weight: 96,558 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein