HOXA1 Sequence-specific transcription factor. Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior. Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments. Activates transcription in the presence of PBX1A and PKNOX1. Belongs to the Antp homeobox family. Labial subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of human Ortholog: 7p15.2
Cellular Component:  chromatin; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
Biological Process:  abducens nerve formation; anatomical structure morphogenesis; artery development; artery morphogenesis; cochlea development; cochlea morphogenesis; cognition; embryonic neurocranium morphogenesis; inner ear development; neuromuscular process; optokinetic behavior; outer ear morphogenesis; positive regulation of transcription by RNA polymerase II; regulation of behavior; regulation of transcription by RNA polymerase II; semicircular canal formation; sensory perception of sound
Disease: Athabaskan Brainstem Dysgenesis Syndrome
Reference #:  P49639 (UniProtKB)
Alt. Names/Synonyms: BSAS; homeo box A1; homeobox 1F; homeobox A1; Homeobox protein Hox-1F; Homeobox protein Hox-A1; Hox 1.6-like protein; HOX A1 homeodomain protein; HOX1; HOX1F; HOXA1; HXA1; lab-like protein; MGC45232
Gene Symbols: HOXA1
Molecular weight: 36,641 Da
Basal Isoelectric point: 8.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB