DGKZ
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes. Activates PIP5K1A activity via generation of phosphatidic acid. Belongs to the eukaryotic diacylglycerol kinase family. Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 11p11.2 |
Cellular Component:
cytoplasm; cytosol; lamellipodium; nuclear speck; nucleus; plasma membrane
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Molecular Function:
ATP binding; ATP-dependent diacylglycerol kinase activity; kinase activity; metal ion binding; protein binding
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Biological Process:
cell migration; diacylglycerol metabolic process; glycerolipid metabolic process; intracellular signal transduction; lipid phosphorylation; negative regulation of T cell receptor signaling pathway; phosphatidic acid biosynthetic process; platelet activation; positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of synaptic transmission, glutamatergic
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Reference #:
Q13574
(UniProtKB)
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Alt. Names/Synonyms: DAG kinase zeta; DAGK5; DAGK6; DGK-zeta; DGKZ; Diacylglycerol kinase zeta; diacylglycerol kinase, zeta 104kDa; Diglyceride kinase zeta; hDGKzeta
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Gene Symbols: DGKZ
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Molecular weight:
103,981 Da
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Basal Isoelectric point:
8.34
Predict pI for various phosphorylation states
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