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MCM4
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Belongs to the MCM family. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication; EC 3.6.4.12 |
| Chromosomal Location of mouse Ortholog: 16 A2|16 10.09 cM |
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Cellular Component:
chromosome; CMG complex; MCM complex; nucleoplasm; nucleus
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Molecular Function:
ATP binding; DNA binding; DNA helicase activity; helicase activity; hydrolase activity; nucleotide binding; protein binding; single-stranded DNA binding; single-stranded DNA helicase activity
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Biological Process:
cell cycle; DNA duplex unwinding; DNA replication; DNA replication initiation; DNA strand elongation involved in DNA replication; DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; mitotic DNA replication initiation; regulation of DNA-templated DNA replication initiation
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Reference #:
P49717
(UniProtKB)
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Alt. Names/Synonyms: 19G; AI325074; AU045576; Cdc21; CDC21 homolog; DNA replication licensing factor MCM4; KIAA4003; mcdc21; Mcm4; Mcmd4; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance complex component 4; minichromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4 homolog (S. cerevisiae); mKIAA4003; P1-CDC21
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Gene Symbols: Mcm4
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Molecular weight:
96,736 Da
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Basal Isoelectric point:
6.77
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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