MCM4 a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. The MCM hexameric protein complex is a key component of the pre-replication complex. The complex consisting of this protein and MCM2, 6 and 7 possesses DNA helicase activity. Phosphorylation by CDC2 reduces the DNA helicase activity and chromatin binding of the complex. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC 3.6.4.12
Chromosomal Location of Human Ortholog: 16 A2|16 10.09 cM
Cellular Component:  MCM complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA binding; DNA replication origin binding; helicase activity; hydrolase activity; nucleotide binding; protein binding; single-stranded DNA binding
Biological Process:  cell cycle; DNA replication; DNA replication initiation; DNA strand elongation involved in DNA replication; DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; mitotic DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication
Reference #:  P49717 (UniProtKB)
Alt. Names/Synonyms: 19G; AI325074; AU045576; Cdc21; CDC21 homolog; DNA replication licensing factor MCM4; KIAA4003; mcdc21; Mcm4; Mcmd4; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4 homolog (S. cerevisiae); mKIAA4003; P1-CDC21
Gene Symbols: Mcm4
Molecular weight: 96,736 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MCM4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene