MCM4 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Belongs to the MCM family. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC 3.6.4.12
Chromosomal Location of Human Ortholog: 16 A2|16 10.09 cM
Cellular Component:  MCM complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA binding; DNA replication origin binding; helicase activity; hydrolase activity; nucleotide binding; protein binding; single-stranded DNA binding
Biological Process:  cell cycle; DNA replication; DNA replication initiation; DNA strand elongation involved in DNA replication; DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; mitotic DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication
Reference #:  P49717 (UniProtKB)
Alt. Names/Synonyms: 19G; AI325074; AU045576; Cdc21; CDC21 homolog; DNA replication licensing factor MCM4; KIAA4003; mcdc21; Mcm4; Mcmd4; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4 homolog (S. cerevisiae); mKIAA4003; P1-CDC21
Gene Symbols: Mcm4
Molecular weight: 96,736 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MCM4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene