PLA2G4B iso6 Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine. Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.1.4; Lipid Metabolism - arachidonic acid; Phospholipase
Cellular Component: 
Reference #:  P0C869-6 (UniProtKB)
Alt. Names/Synonyms: cPLA2-beta; Cytosolic phospholipase A2 beta; HsT16992; PA24B; Phospholipase A2 group IVB; phospholipase A2, group IVB (cytosolic); PLA2G4B; PLA2G4B iso6
Gene Symbols: PLA2G4B
Molecular weight: 114,121 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Select Structure to View Below

PLA2G4B iso6

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene