MTAP iso2 Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. Ubiquitously expressed. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC 2.4.2.28; Phosphorylase; Transferase
Cellular Component: 
Reference #:  Q13126-2 (UniProtKB)
Alt. Names/Synonyms: 5'-methylthioadenosine phosphorylase; BDMF; c86fus; DMSFH; DMSMFH; epididymis luminal protein 249; epididymis secretory sperm binding protein; HEL-249; LGMBF; MeSAdo phosphorylase; methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAP iso2; MTAPase; S-methyl-5'-thioadenosine phosphorylase
Gene Symbols: MTAP
Molecular weight: 38,356 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
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MTAP iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene