HuR iso2
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR. Belongs to the RRM elav family. Ubiquitous. Detected in brain, liver, thymus and muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: RNA-binding |
Chromosomal Location of human Ortholog: 19p13.2 |
Cellular Component:
cytoplasm; cytoplasmic stress granule; cytoplasmic vesicle; cytosol; endoplasmic reticulum; glutamatergic synapse; nucleoplasm; nucleus; P-body; postsynapse; ribonucleoprotein complex; sarcoplasm
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Molecular Function:
double-stranded RNA binding; lncRNA binding; miRNA binding; mRNA 3'-UTR AU-rich region binding; mRNA 3'-UTR binding; mRNA binding; protein binding; protein homodimerization activity; protein kinase binding; RNA binding
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Biological Process:
3'-UTR-mediated mRNA stabilization; mRNA stabilization; negative regulation of miRNA-mediated gene silencing; positive regulation of translation; post-transcriptional gene silencing; protein homooligomerization; protein import into nucleus; regulation of stem cell population maintenance
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Reference #:
Q15717-2
(UniProtKB)
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Alt. Names/Synonyms: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV like RNA binding protein 1; ELAV-like protein 1; ELAV1; ELAVL1; embryonic lethal, abnormal vision, drosophila, homolog-like 1; Hu antigen R; Hu-antigen R; Hua; HUR; HuR iso2; MelG
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Gene Symbols: ELAVL1
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Molecular weight:
38,996 Da
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Basal Isoelectric point:
9.49
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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