ITSN2 iso4 Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. Expressed in melanocytes (PubMed:23999003). Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: 
Reference #:  Q9NZM3-4 (UniProtKB)
Alt. Names/Synonyms: intersectin 2; Intersectin-2; ITSN2; ITSN2 iso4; KIAA1256; PRO2015; SH3 domain protein 1B; SH3 domain-containing protein 1B; SH3D1B; SH3P18; SH3P18-like WASP associated protein; SH3P18-like WASP-associated protein; SWA; SWAP
Gene Symbols: ITSN2
Molecular weight: 135,144 Da
Basal Isoelectric point: 8.03  Predict pI for various phosphorylation states
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ITSN2 iso4

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene