AKAP9 iso6 Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery. Isoform 4: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Widely expressed (PubMed:10202149). Isoform 4: Highly expressed in skeletal muscle and in pancreas (PubMed:9482789). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: 
Reference #:  Q99996-6 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein (yotiao) 9; A kinase (PRKA) anchor protein 9; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; A-kinase anchor protein 9; A-kinase anchor protein, 350kDa; A-kinase anchoring protein 450; A-kinase anchoring protein 9; AKAP 120-like protein; AKAP 350; AKAP 450; AKAP-9; AKAP120-like protein; AKAP350; AKAP450; AKAP9; AKAP9 iso6; AKAP9-BRAF fusion partner; AKAP9-BRAF fusion protein; Centrosome- and Golgi-localized PKN-associated protein; centrosome- and golgi-localized protein; centrosome- and golgi-localized protein kinase N-associated protein; CG-NAP; hgAKAP 350; HYPERION; KIAA0803; kinase N-associated protein; LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; Protein hyperion; protein kinase A anchoring protein 9; Protein kinase A-anchoring protein 9; protein phosphatase 1, regulatory subunit 45; Protein yotiao; YOTIAO
Gene Symbols: AKAP9
Molecular weight: 455,424 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
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AKAP9 iso6

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene