IGFBP3 iso2 IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Expressed by most tissues. Present in plasma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 7p12.3
Cellular Component: 
Reference #:  P17936-2 (UniProtKB)
Alt. Names/Synonyms: acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP-53; growth hormone-dependent binding protein; IBP-3; IBP3; IGF-binding protein 3; IGFBP-3; IGFBP3; IGFBP3 iso2; insulin like growth factor binding protein 3; insulin-like growth factor binding protein 3; Insulin-like growth factor-binding protein 3
Gene Symbols: IGFBP3
Molecular weight: 32,223 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
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IGFBP3 iso2

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene