PPP3CB iso4 Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Belongs to the PPP phosphatase family. PP-2B subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component: 
Reference #:  P16298-4 (UniProtKB)
Alt. Names/Synonyms: calcineurin A beta; calcineurin A2; Calmodulin-dependent calcineurin A subunit beta isoform; CALNA2; CALNB; CAM-PRP catalytic subunit; CNA beta; CNA2; PP2BB; PP2Bbeta; PPP3CB; PPP3CB iso4; protein phosphatase 2B, catalytic subunit, beta isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform; protein phosphatase 3 catalytic subunit beta; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase from PCR fragment H32; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Gene Symbols: PPP3CB
Molecular weight: 59,123 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Mitochondrial Control of Apoptosis  |  T Cell Receptor Signaling
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PPP3CB iso4

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene