BLOC1S1 May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 AND NDUFA9. May also be involved in the biogenesis of specialized organelles of the endosomal-lysosomal system. Belongs to the BLOC1S1 family. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Vesicle
Chromosomal Location of Human Ortholog: 10 D3|10 77.19 cM
Cellular Component:  BLOC-1 complex; BORC complex; cytoplasm; cytosol; early endosome; lysosome; membrane; mitochondrial intermembrane space; mitochondrial matrix
Molecular Function:  protein binding
Biological Process:  aerobic respiration; anterograde axonal transport; anterograde synaptic vesicle transport; endosomal transport; lysosome localization; neuron projection development; peptidyl-lysine acetylation
Reference #:  O55102 (UniProtKB)
Alt. Names/Synonyms: AI839753; Biogenesis of lysosome-related organelles complex 1 subunit 1; biogenesis of lysosome-related organelles complex-1, subunit 1; BL1S1; BLOC-1 subunit 1; Bloc1s1; BLOS1; GCN5 general control of amino acid synthesis-like 1; GCN5-like protein 1; Gcn5l1; general control of amino acid synthesis, yeast homolog-like 1; general control of amino acid synthesis-like 1
Gene Symbols: Bloc1s1
Molecular weight: 14,281 Da
Basal Isoelectric point: 7.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein