BLOC1S1 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Belongs to the BLOC1S1 family. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Vesicle
Chromosomal Location of Human Ortholog: 10 D3|10 77.19 cM
Cellular Component:  BLOC-1 complex; BORC complex; cytoplasm; cytosol; early endosome; lysosome; membrane; mitochondrial intermembrane space; mitochondrial matrix
Molecular Function:  protein binding
Biological Process:  aerobic respiration; anterograde axonal transport; anterograde synaptic vesicle transport; endosomal transport; lysosome localization; neuron projection development; peptidyl-lysine acetylation
Reference #:  O55102 (UniProtKB)
Alt. Names/Synonyms: AI839753; Biogenesis of lysosome-related organelles complex 1 subunit 1; biogenesis of lysosome-related organelles complex-1, subunit 1; BL1S1; BLOC-1 subunit 1; Bloc1s1; BLOS1; GCN5 general control of amino acid synthesis-like 1; GCN5-like protein 1; Gcn5l1; general control of amino acid synthesis, yeast homolog-like 1; general control of amino acid synthesis-like 1
Gene Symbols: Bloc1s1
Molecular weight: 14,281 Da
Basal Isoelectric point: 7.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein