BLOC1S1
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Belongs to the BLOC1S1 family. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Acetyltransferase; Nuclear receptor co-regulator; Vesicle |
Chromosomal Location of mouse Ortholog: 10 D3|10 77.19 cM |
Cellular Component:
BLOC-1 complex; BORC complex; cytoplasm; cytoplasmic side of lysosomal membrane; cytosol; early endosome; lysosome; membrane; mitochondrial intermembrane space; mitochondrial matrix
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Molecular Function:
protein binding
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Biological Process:
aerobic respiration; anterograde axonal transport; anterograde synaptic vesicle transport; endosomal transport; lysosome localization; melanosome organization; neuron projection development; organelle transport along microtubule; peptidyl-lysine acetylation; regulation of endosome size; regulation of lysosome size
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Reference #:
O55102
(UniProtKB)
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Alt. Names/Synonyms: AI839753; biogenesis of lysosomal organelles complex-1, subunit 1; Biogenesis of lysosome-related organelles complex 1 subunit 1; biogenesis of lysosome-related organelles complex-1, subunit 1; BL1S1; BLOC-1 subunit 1; Bloc1s1; BLOS1; Gcn5; GCN5 general control of amino acid synthesis-like 1; GCN5-like protein 1; Gcn5l1; general control of amino acid synthesis, yeast homolog-like 1; general control of amino acid synthesis-like 1
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Gene Symbols: Bloc1s1
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Molecular weight:
14,281 Da
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Basal Isoelectric point:
7.88
Predict pI for various phosphorylation states
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