CCR2 Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion. Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Faciltates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Mediates the recruitment of macrophages and monocytes to the injury site following brain injury. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. Expressed by monocytes and IL2-activated NK cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 3p21.31
Cellular Component:  cytoplasm; cytosol; dendrite; external side of plasma membrane; fibrillar center; membrane; neuronal cell body; perikaryon; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  C-C chemokine binding; C-C chemokine receptor activity; CCR2 chemokine receptor binding; chemokine (C-C motif) ligand 12 binding; chemokine (C-C motif) ligand 2 binding; chemokine (C-C motif) ligand 7 binding; chemokine receptor activity; identical protein binding; protein binding
Biological Process:  blood vessel remodeling; calcium-mediated signaling; cell chemotaxis; cellular defense response; cellular homeostasis; chemokine-mediated signaling pathway; chemotaxis; cytokine-mediated signaling pathway; dendritic cell chemotaxis; G protein-coupled receptor signaling pathway; hemopoiesis; homeostasis of number of cells within a tissue; humoral immune response; immune response; inflammatory response; inflammatory response to wounding; intracellular calcium ion homeostasis; leukocyte adhesion to vascular endothelial cell; macrophage migration; monocyte chemotaxis; monocyte extravasation; negative regulation of adenylate cyclase activity; negative regulation of angiogenesis; negative regulation of eosinophil degranulation; negative regulation of type 2 immune response; neutrophil clearance; positive regulation of alpha-beta T cell proliferation; positive regulation of astrocyte chemotaxis; positive regulation of CD8-positive, alpha-beta T cell extravasation; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of hematopoietic stem cell migration; positive regulation of immune complex clearance by monocytes and macrophages; positive regulation of inflammatory response; positive regulation of interleukin-2 production; positive regulation of leukocyte tethering or rolling; positive regulation of monocyte chemotaxis; positive regulation of monocyte extravasation; positive regulation of NMDA glutamate receptor activity; positive regulation of synaptic transmission, glutamatergic; positive regulation of T cell activation; positive regulation of T cell chemotaxis; positive regulation of T-helper 1 type immune response; positive regulation of thymocyte migration; positive regulation of tumor necrosis factor production; positive regulation of type II interferon production; receptor signaling pathway via JAK-STAT; regulation of inflammatory response; regulation of macrophage migration; regulation of T cell cytokine production; regulation of T cell differentiation; regulation of vascular endothelial growth factor production; response to wounding; sensory perception of pain; T-helper 17 cell chemotaxis
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Polycystic Lung Disease
Reference #:  P41597 (UniProtKB)
Alt. Names/Synonyms: C-C chemokine receptor type 2; C-C CKR-2; C-C motif chemokine receptor 2; CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CKR2B; CMKBR2; FLJ78302; MCP-1 receptor; MCP-1-R; MGC103828; MGC111760; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Gene Symbols: CCR2
Molecular weight: 41,915 Da
Basal Isoelectric point: 9.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein