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CYP21A2
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. Belongs to the cytochrome P450 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.14.99.10; Lipid Metabolism - C21-steroid hormone; Oxidoreductase |
| Chromosomal Location of human Ortholog: 6p21.33 |
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Cellular Component:
endoplasmic reticulum membrane
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Molecular Function:
17-hydroxyprogesterone 21-hydroxylase activity; heme binding; iron ion binding; progesterone 21-hydroxylase activity; steroid 21-monooxygenase activity; steroid binding; steroid hydroxylase activity
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Biological Process:
glucocorticoid biosynthetic process; mineralocorticoid biosynthetic process; steroid biosynthetic process; steroid metabolic process; sterol metabolic process
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Disease: Adrenal Hyperplasia, Congenital, Due To 21-hydroxylase Deficiency
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Reference #:
P08686
(UniProtKB)
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Alt. Names/Synonyms: 21-hydroxylase; 21-OHase; CA21H; CAH1; CP21A; CPS1; CYP21; CYP21A2; CYP21B; Cytochrome P-450c21; Cytochrome P450 21; cytochrome P450 family 21 subfamily A member 2; Cytochrome P450 XXI; cytochrome P450, family 21, subfamily A, polypeptide 2; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2; Cytochrome P450-C21; Cytochrome P450-C21B; MGC150536; MGC150537; P450c21B; steroid 21 hydroxylase; Steroid 21-hydroxylase; steroid 21-monooxygenase
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Gene Symbols: CYP21A2
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Molecular weight:
56,001 Da
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Basal Isoelectric point:
7.71
Predict pI for various phosphorylation states
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