BMAL1 a transcriptional activator protein that forms a core component of the circadian clock. An aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Nine splice isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 11p15.3
Cellular Component:  chromatoid body; intracellular membrane-bounded organelle; nucleoplasm; nucleus; PML body; transcription factor complex
Molecular Function:  aryl hydrocarbon receptor binding; bHLH transcription factor binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; Hsp90 protein binding; protein binding; protein heterodimerization activity; repressing transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region sequence-specific DNA binding
Biological Process:  circadian regulation of gene expression; circadian rhythm; maternal process involved in parturition; negative regulation of cold-induced thermogenesis; negative regulation of fat cell differentiation; negative regulation of glucocorticoid receptor signaling pathway; negative regulation of TOR signaling; negative regulation of transcription, DNA-templated; oxidative stress-induced premature senescence; positive regulation of canonical Wnt signaling pathway; positive regulation of circadian rhythm; positive regulation of protein acetylation; positive regulation of skeletal muscle cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; protein import into nucleus; regulation of cell cycle; regulation of cellular senescence; regulation of hair cycle; regulation of insulin secretion; regulation of neurogenesis; regulation of protein catabolic process; regulation of transcription, DNA-templated; regulation of type B pancreatic cell development; response to redox state; spermatogenesis
Reference #:  O00327 (UniProtKB)
Alt. Names/Synonyms: ARNT-like protein 1, brain and muscle; ARNTL; aryl hydrocarbon receptor nuclear translocator like; aryl hydrocarbon receptor nuclear translocator-like; Aryl hydrocarbon receptor nuclear translocator-like protein 1; basic helix-loop-helix family member e5; basic-helix-loop-helix-PAS orphan MOP3; Basic-helix-loop-helix-PAS protein MOP3; bHLH-PAS protein JAP3; BHLHE5; BMAL; BMAL1; BMAL1c; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; JAP3; Member of PAS protein 3; member of PAS superfamily 3; MGC47515; MOP3; PAS domain containing 3; PAS domain-containing protein 3; PASD3; testis tissue sperm-binding protein Li 50e; TIC
Gene Symbols: ARNTL
Molecular weight: 68,762 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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BMAL1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene