RAB23 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of mouse Ortholog: 1 B|1 12.8 cM
Cellular Component:  autophagosome; cell junction; centrosome; cytoplasm; cytoplasmic vesicle; cytosol; endosome; endosome membrane; membrane; phagocytic vesicle; plasma membrane
Molecular Function:  GTP binding; GTPase activity; nucleotide binding
Biological Process:  autophagosome assembly; cellular defense response; cilium assembly; craniofacial suture morphogenesis; dorsal/ventral neural tube patterning; embryonic digit morphogenesis; GTP metabolic process; intracellular protein transport; multicellular organism development; negative regulation of protein import into nucleus; negative regulation of proteolysis; nervous system development; neural tube closure; protein transport; Rab protein signal transduction; regulation of smoothened signaling pathway; signal transduction; spinal cord dorsal/ventral patterning
Reference #:  P35288 (UniProtKB)
Alt. Names/Synonyms: AW545388; opb; opb2; open brain 2; OTTMUSP00000024509; OTTMUSP00000024510; Protein open brain; rab-15; Rab23; RAB23, member RAS oncogene family; RAB23, member RAS oncogene family, isoform CRA_a; Ras-related protein Rab-23
Gene Symbols: Rab23
Molecular weight: 26,678 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene