LRAT
Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology. Belongs to the H-rev107 family. Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain. Note: This description may include information from UniProtKB.
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Protein type: Cofactor and Vitamin Metabolism - retinol; EC 2.3.1.135; Membrane protein, integral; Transferase |
Chromosomal Location of human Ortholog: 4q32.1 |
Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; multivesicular body; perinuclear region of cytoplasm; rough endoplasmic reticulum
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Molecular Function:
acyltransferase activity; lecithin:11-cis retinol acyltransferase activity; O-palmitoyltransferase activity; phosphatidylcholine-retinol O-acyltransferase activity; protein binding; retinoic acid binding; retinol binding
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Biological Process:
cellular response to leukemia inhibitory factor; positive regulation of lipid transport; response to bacterium; response to retinoic acid; response to vitamin A; retinoid metabolic process; retinol metabolic process; visual perception; vitamin A metabolic process
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Disease: Leber Congenital Amaurosis 14; Retinitis Pigmentosa
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Reference #:
O95237
(UniProtKB)
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Alt. Names/Synonyms: LCA14; Lecithin retinol acyltransferase; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase); LRAT; MGC33103; Phosphatidylcholine--retinol O-acyltransferase
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Gene Symbols: LRAT
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Molecular weight:
25,703 Da
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Basal Isoelectric point:
7.01
Predict pI for various phosphorylation states
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