FMO3 Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. Belongs to the FMO family. Liver. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Chromosomal Location of Human Ortholog: 1q24.3
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane; intracellular membrane-bounded organelle
Molecular Function:  flavin adenine dinucleotide binding; N,N-dimethylaniline monooxygenase activity; NADP binding; protein binding; trimethylamine monooxygenase activity
Biological Process:  oxidation-reduction process; xenobiotic metabolic process
Disease: Trimethylaminuria
Reference #:  P31513 (UniProtKB)
Alt. Names/Synonyms: Dimethylaniline monooxygenase [N-oxide-forming] 3; Dimethylaniline oxidase 3; dJ127D3.1; flavin containing dimethylaniline monoxygenase 3; flavin containing monooxygenase 3; FMO 3; FMO form 2; FMO II; FMO3; FMOII; Hepatic flavin-containing monooxygenase 3; hepatic flavin-containing monooxygenase-3; MGC34400; TMAU; Trimethylamine monooxygenase
Gene Symbols: FMO3
Molecular weight: 60,033 Da
Basal Isoelectric point: 7.9  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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