IL6 Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. Belongs to the IL-6 superfamily. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7p15.3
Cellular Component:  endoplasmic reticulum lumen; extracellular region; extracellular space; interleukin-6 receptor complex
Molecular Function:  cytokine activity; growth factor activity; interleukin-6 receptor binding; protein binding
Biological Process:  acute-phase response; cellular protein metabolic process; cellular response to hydrogen peroxide; cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; defense response to virus; endocrine pancreas development; glucagon secretion; hepatic immune response; humoral immune response; inflammatory response; interleukin-6-mediated signaling pathway; monocyte chemotaxis; negative regulation of apoptotic process; negative regulation of bone resorption; negative regulation of cell proliferation; negative regulation of chemokine biosynthetic process; negative regulation of collagen biosynthetic process; negative regulation of fat cell differentiation; negative regulation of interleukin-1-mediated signaling pathway; negative regulation of lipid storage; negative regulation of neurogenesis; neuron cellular homeostasis; neuron projection development; neutrophil apoptotic process; neutrophil mediated immunity; platelet activation; positive regulation of acute inflammatory response; positive regulation of apoptotic DNA fragmentation; positive regulation of apoptotic process; positive regulation of B cell activation; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of DNA-binding transcription factor activity; positive regulation of epithelial to mesenchymal transition; positive regulation of extracellular matrix disassembly; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of immunoglobulin secretion; positive regulation of interleukin-17 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of JAK-STAT cascade; positive regulation of leukocyte chemotaxis; positive regulation of MAPK cascade; positive regulation of neuroinflammatory response; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell cytokine production; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of translation; positive regulation of type B pancreatic cell apoptotic process; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial growth factor production; post-translational protein modification; regulation of angiogenesis; regulation of astrocyte activation; regulation of maintenance of permeability of blood-brain barrier; regulation of microglial cell activation; regulation of neuroinflammatory response; regulation of signaling receptor activity; regulation of vascular endothelial growth factor production; response to glucocorticoid; response to peptidoglycan; T-helper 17 cell lineage commitment
Disease: Arteriovenous Malformations Of The Brain; Diabetes Mellitus, Insulin-dependent; Inflammatory Bowel Disease 1; Kaposi Sarcoma, Susceptibility To; Rheumatoid Arthritis, Systemic Juvenile
Reference #:  P05231 (UniProtKB)
Alt. Names/Synonyms: B cell stimulatory factor-2; B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; BSF2; CDF; CTL differentiation factor; HGF; HSF; Hybridoma growth factor; IFN-beta-2; IFNB2; IL-6; IL6; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; Interleukin-6
Gene Symbols: IL6
Molecular weight: 23,718 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB