ASB1
May play a role in testis development. Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Belongs to the ankyrin SOCS box (ASB) family. Note: This description may include information from UniProtKB.
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Chromosomal Location of human Ortholog: 2q37.3 |
Cellular Component:
cytosol; ubiquitin ligase complex
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Molecular Function:
protein binding; ubiquitin protein ligase activity
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Biological Process:
intracellular signal transduction; male genitalia development; negative regulation of cytokine production; protein ubiquitination
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Reference #:
Q9Y576
(UniProtKB)
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Alt. Names/Synonyms: ankyrin repeat and SOCS box containing 1; Ankyrin repeat and SOCS box protein 1; ankyrin repeat and SOCS box-containing 1; ASB-1; ASB1; KIAA1146; MGC11165
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Gene Symbols: ASB1
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Molecular weight:
37,014 Da
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Basal Isoelectric point:
8.55
Predict pI for various phosphorylation states
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