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ITGA5
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 12q13.13 |
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Cellular Component:
alphav-beta3 integrin-vitronectin complex; cell surface; cell-cell junction; cytoplasmic vesicle; endoplasmic reticulum; external side of plasma membrane; focal adhesion; glutamatergic synapse; Golgi apparatus; integrin alpha5-beta1 complex; integrin complex; plasma membrane; postsynaptic membrane; ruffle; ruffle membrane
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Molecular Function:
epidermal growth factor receptor binding; integrin binding; metal ion binding; platelet-derived growth factor receptor binding; protein binding; vascular endothelial growth factor receptor 2 binding; virus receptor activity
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Biological Process:
angiogenesis; CD40 signaling pathway; cell adhesion; cell adhesion mediated by integrin; cell-cell adhesion; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; endodermal cell differentiation; female pregnancy; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; memory; negative regulation of anoikis; positive regulation of cell migration; positive regulation of cell-substrate adhesion; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of sprouting angiogenesis; positive regulation of vascular endothelial growth factor receptor signaling pathway; viral entry into host cell; wound healing, spreading of epidermal cells
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Reference #:
P08648
(UniProtKB)
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Alt. Names/Synonyms: CD49 antigen-like family member E; CD49e; Fibronectin receptor subunit alpha; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; FNRA; Integrin alpha-5; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; integrin subunit alpha 5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITA5; ITGA5; ITGA5/SLC9B1 fusion; very late activation protein 5, alpha subunit; VLA-5; VLA5A
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Gene Symbols: ITGA5
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Molecular weight:
114,536 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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