TAF1 Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: ATYPICAL group; DNA-binding; EC 2.3.1.48; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; TAF1 family; Transcription, coactivator/corepressor

Chromosomal Location of human Ortholog: Xq13.1

Cellular Component: chromatin; MLL1 complex; nucleolus; nucleoplasm; nucleus; transcription factor TFIID complex; transcription regulator complex

Molecular Function: acetyl-CoA binding; ATP binding; H3K27me3 modified histone binding; histone acetyltransferase activity; kinase activity; lysine-acetylated histone binding; nuclear receptor binding; p53 binding; protein binding; protein heterodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase I general transcription initiation factor activity; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II general transcription initiation factor activity; RNA polymerase II general transcription initiation factor binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; TBP-class protein binding; transcription regulator inhibitor activity; ubiquitin conjugating enzyme activity

Biological Process: cell cycle; cellular response to ATP; cellular response to UV; chromatin remodeling; DNA damage response; midbrain development; mRNA transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of protein autoubiquitination; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; negative regulation of transcription by RNA polymerase II; negative regulation of ubiquitin-dependent protein catabolic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of androgen receptor activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein autophosphorylation; protein phosphorylation; protein polyubiquitination; protein stabilization; regulation of cell cycle G1/S phase transition; regulation of signal transduction by p53 class mediator; RNA polymerase II preinitiation complex assembly; transcription by RNA polymerase II; transcription initiation at RNA polymerase I promoter; transcription initiation at RNA polymerase II promoter; ubiquitin-dependent protein catabolic process

Disease: Dystonia 3, Torsion, X-linked; Mental Retardation, X-linked, Syndromic 33

Reference #: P21675 (UniProtKB)

Alt. Names/Synonyms: BA2R; CCG1; CCGS; Cell cycle gene 1 protein; cell cycle, G1 phase defect; complementation of cell cycle block, G1-to-S; DYT3; DYT3/TAF1; KAT4; MRXS33; N-TAF1; NSCL2; OF; p250; TAF(II)250; TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; TAF2A; TAFII-250; TAFII250; TATA-box binding protein associated factor 1; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; Transcription initiation factor TFIID 250 kDa subunit; Transcription initiation factor TFIID subunit 1; XDP

Gene Symbols: TAF1

Molecular weight: 214,714 Da

Basal Isoelectric point: 4.95 Predict pI for various phosphorylation states

CST Pathways: Protein Acetylation

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

Select Structure to View Below
TAF1

Get PyMOL Script Get Chimera Script