GTF2A1 a general transcription factor that plays an important role in transcriptional activation. A component of the transcription machinery of RNA polymerase II. Phosphorylated by Taf(II) 250 on serines that regulate TBP binding. Interacts with TBP (the TATA-binding protein). Two isoforms, 42 kDa and 37 kDa, are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 14q31.1
Cellular Component:  cytosol; nucleoplasm; transcription factor TFIIA complex; transcription factor TFIID complex
Molecular Function:  DNA binding; protein binding; protein heterodimerization activity; RNA polymerase II general transcription initiation factor activity; RNA polymerase II repressing transcription factor binding; TBP-class protein binding; transcription coactivator activity; transcription factor binding
Biological Process:  positive regulation of nucleic acid-templated transcription; snRNA transcription by RNA polymerase II; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter
Reference #:  P52655 (UniProtKB)
Alt. Names/Synonyms: General transcription factor IIA subunit 1; GTF2A1; TF2A1; TF2AA; TFIIA p19 subunit; TFIIA p35 subunit; TFIIA-42; TFIIAL; Transcription initiation factor IIA alpha chain; Transcription initiation factor IIA beta chain; Transcription initiation factor IIA subunit 1; Transcription initiation factor TFIIA 42 kDa subunit; UNGP3
Gene Symbols: GTF2A1
Molecular weight: 41,514 Da
Basal Isoelectric point: 4.4  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
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Protein Structure Not Found.

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